ANTIMICROBIAL PEPTIDE LL-37 FACILITATES INTRACELLULAR UPTAKE OF RNA APTAMER APT 21-2 WITHOUT INDUCING AN INFLAMMATORY OR INTERFERON RESPONSE

Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response

RNA aptamers are synthetic single stranded RNA oligonucleotides Sling Shot that function analogously to antibodies.Recently, they have shown promise for use in treating inflammatory skin disease as, unlike antibody-based biologics, they are able to enter the skin following topical administration.However, it is important to understand the inflammato

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A prospective study to evaluate the utility of bronchoalveolar lavage by fiberoptic bronchoscopy in sputum smear negative patients with high suspicion of pulmonary tuberculosis

Aim: To evaluate the utility of bronchoalveolar lavage (BAL) by flexible fiberoptic bronchoscopy (FOB) in sputum smear negative patients with clinical and radiological characteristics of pulmonary tuberculosis (PTB).Materials and Methods: This prospective study was carried out in 30 sputum smear negative patients of age group 20 to 70 years, who we

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